Dino

β2-Microglobulin

β2-Microglobulin

Synonyms β2-Microglobulin; β2-M

CAS Number: Not applicable

MDL Number: MFCD00130615

Packaging size: 500 µg

SKU 02153903.5
Price:
$410.80
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Description

Product Description

β2-Microglobulin

Application Notes

To study the effect of β2 microglobulin , mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of β2 microglobulin can indicate non-progression of HIV.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Stability of the MHC antigens

Specifications
SKU 02153903.5
Application Notes To study the effect of β2 microglobulin , mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of β2 microglobulin can indicate non-progression of HIV.
Biochemical Physiological Actions A transient complex of MHC heavy chain and β2-Microglobulin is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-Microglobulin complex to the cell surface. Absence of binding leads to degradation in the proteasome.
Certifications Tested and found negative for HIV 1&2, Hepatitis B, and Hepatitis C.
Format solid
Formulation Details Lyophilized from 0.02 M NH4(HCO3)
Applications Stability of the MHC antigens
Pack Size 500 µg
Physical Appearance White Solid
Product Families Description β-2-Microglobulin
Product Overview β2-Microglobulin
Purity 30 - 60 %
Source Human Urine
Storage and Handling Store at -20 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.