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Flurbiprofen

Flurbiprofen

Synonyms (±)-2-Fluoro-α-methyl-4-biphenylacetic acid; L-790,330

CAS Number: 5104-49-4 Molecular Formula: C15H13FO2 Molecular Weight: 244.265 g/mol

EC Number: 225-827-6 MDL Number: MFCD00079303

Packaging size: 25 g

SKU 0215816325
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Description

Product Description

Flurbiprofen

Application Notes

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat and the biotransformation of flurbiprofen by Cunninghamella species.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Anti-inflammatory agent

Specifications
SKU 0215816325
Application Notes Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat and the biotransformation of flurbiprofen by Cunninghamella species.
Biochemical Physiological Actions Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
EC Number 225-827-6
Format powder
Hazard Statements H301
Applications Anti-inflammatory agent
Melting Point 110-111 °C
Molecular Formula C15H13FO2
Molecular Weight 244.265 g/mol
Pack Size 25 g
Personal Protective Equipment Eyeshields, Faceshields, Gloves, respirator cartridges
Physical Appearance White Powder
Product Families Description Flurbiprofen
Product Overview Flurbiprofen
RTECS Number DU8341000
Safety Symbol GHS06
Solubility Water Solubility8 mg/L (at 22 °C)
Storage and Handling Store at Room Temperature (15-30 °C).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.