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Human Fibrinogen, Plasminogen Depleted

Human Fibrinogen, Plasminogen Depleted

Synonyms Factor 1

CAS Number: 9001-32-5 Molecular Weight: 182.172 g/mol

Packaging size: 1 g

SKU 03BC0501
Price:
$390.00
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Description

Product Description

Human Fibrinogen, Plasminogen Depleted

Application Notes

Fibrinogen, or Factor I, is a blood protein that is involved in clotting and is converted to fibrin by thrombin

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications
SKU 03BC0501
Analysis Note Human fibrinogen was purified from human plasma that was tested and found negative for all communicable diseases, including HIV-1, HIV-2, Hepatitis Surface antigen and HCV. Donors are screened for CJD (Creutzfeldt-Jakob Disease).The plasminogen was depleted using affinity chromatography.
Application Notes Fibrinogen, or Factor I, is a blood protein that is involved in clotting and is converted to fibrin by thrombin
Biochemical Physiological Actions Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyses fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
Formulation Details Buffer: 20 mM Sodium citrate-HCl; pH 7.4
Molecular Weight 182.172 g/mol
Pack Size 1 g
Product Families Description Human Fibrinogen
Product Overview Human Fibrinogen, Plasminogen Depleted
Protein or Enzyme Type Plasma & Blood Proteins
Source Human plasma
Storage and Handling Store at -80 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.