ACTIVATED PENETRATIN 1

ACTIVATED PENETRATIN 1

Synonyms Transfection Reagent

Molecular Weight: 2588

Packaging size: 500 g

SKU 11PENA0500
Price:
$548.25
In Stock
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Description

Product Description

The Active Penetratin™ 1 Peptide Transfection reagent features a patented 16 amino acid peptide corresponding to the third helix of the homeodomain of the Antennapedia protein (pAntp) from Drosophila melanogaster.

Application Notes

Activated Penetratin™ 1 Peptide is a novel tool for peptide and siRNA delivery. It has been successfully used to internalize covalently attached peptides, oligonucleotides, and siRNA. It is sold ready for coupling to peptides or oligonucleotides containing thiol (-SH) functions.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Transfection

Specifications
SKU 11PENA0500
Application Notes Activated Penetratin™ 1 Peptide is a novel tool for peptide and siRNA delivery. It has been successfully used to internalize covalently attached peptides, oligonucleotides, and siRNA. It is sold ready for coupling to peptides or oligonucleotides containing thiol (-SH) functions.
Cells Tested Adherent and suspension cell lines
Chemical Class Peptide
Format powder
Applications Transfection
Molecular Weight 2588
Pack Size 500 g
Personal Protective Equipment Personal-protective-equipment: If working with biological, toxic, hazardous or infectious samples; Hand protection: Latex, Nitrile or other plastic material gloves. Skin and body protection: Labcoat and sleves. Eye protection: Safety glasses with side-shields Hygiene measures: Handle in accordance with good industrial hygiene and safety practice.
Physical Appearance Lyophilized Solid
Presentation Lyophilized Solid
Product Overview Penetratin™ 1 is a patented 16-amino acid peptide corresponding to the third helix of the homeodomain of antennapedeia protein. This peptide is able to translocate across biological membranes by an energy-independent mechanism (1-3) and has been used successfully to internalize covalently attached peptides (4), oligonucleotides (5) and siRNA (6). Activated Penetratin™ 1 is sold ready for coupling to peptides or oligos containing thiol (-SH) functions. Biotinylated Activated Penetratin™ 1 possesses a biotin group at the C-terminal end allowing the detection of the internalized molecule with an appropriate avidin or streptavidin reagent.
Purity HPLC Purified
References 1. Damante G. et al., (1996) EMBO J. 15, 4992-500||2. Dorn A. et al. (1994) Pharmac. Ther. 61,155-183||3. Prochiantz A. (1996) Curr. Opin. Neurobiol. 6, 629-634||4. Derossi D. et al., (1996) J Biol. Chem. 271,18188-18193||5. Brian R et al., (2004) J. Exp. Med 4,547-557||6. Davidson T.J. et al., (2004) J. of Neuroscience. 24 (45), 10040-10046
Research Areas Cell Viability & Cytotoxicity||Cell Cycle||Cell Metabolism
Storage and Handling Stable for two years when frozen (< -15 °C).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.